Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10909241 | Leukemia Research | 2012 | 4 Pages |
Abstract
Cytokines play a central role in multiple myeloma (MM) pathogenesis thus genetic variations within cytokines coding genes could influence MM susceptibility and therapy outcome. We investigated the impact of 8 SNPs in these genes in 202 MM cases and 235 controls also evaluating their impact on therapy outcome in a subset of 91 patients. Despite the overall negative findings, we found a significant age-modified effect of IL6 and TNF-α SNPs, on MM risk and therapy outcome, respectively. Therefore, this observation suggests that genetic variation in inflammation-related genes could be an important mediator of the complex interplay between ageing and cancer.
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Authors
Alessandro Martino, Gabriele Buda, Valentina Maggini, Francesco Lapi, Antonella Lupia, Domenica Di Bello, Enrico Orciuolo, Sara Galimberti, Roberto Barale, Mario Petrini, Anna Maria Rossi,