Article ID Journal Published Year Pages File Type
10909389 Leukemia Research 2011 6 Pages PDF
Abstract
► Inhibition of NHE1 by cariporide in K562 decreases the pHi. ► VEGF secretion by K562 is inhibited upon cariporide treatment. ► HUVECs proliferation and migration are inhibited partially through decreased VEGF. ► In vitro tube formation is also inhibited partially by VEGF down-regulation. ► Microvessel density is decreased in cariporide treated K562 xenograft tumor.
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Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
Preview
Inhibition of K562 leukemia angiogenesis and growth by selective Na+/H+ exchanger inhibitor cariporide through down-regulation of pro-angiogenesis factor VEGF
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