Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10909470 | Leukemia Research | 2011 | 7 Pages |
Abstract
The aim of our study was to estimate the usefulness for conventional cytogenetics (CC) of DSP30 as a single agent (CC-DSP30) for detecting the most important chromosomal aberrations revealed in CLL by FISH and to find other abnormalities possibly existing but undetected by FISH with standard probes. Using CC-DSP30, the metaphases suitable for analysis were obtained in 90% of patients. CC-DSP30 and FISH were similarly efficacious for detecting del(11)(q22) and trisomy 12, whereas FISH was more sensitive for del(13)(q14). Sole del(13)(q14) detected by FISH, in 50% of patients was associated with other aberrations revealed by CC-DSP30. Additionally, the most recurrent anomaly detected by CC-DSP30 were structural aberrations of chromosome 2.
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Authors
Aleksandra Kotkowska, Ewa Wawrzyniak, Jerzy Z. Blonski, Tadeusz Robak, Anna Korycka-Wolowiec,