Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10909511 | Leukemia Research | 2005 | 8 Pages |
Abstract
In this paper we show that in resting Filgrastim (non-glycosylated G-CSF)-pulsed cells, F-actin polymerization, membrane-linked RhoA and cell polarization are enhanced compared to those found in resting Lenograstim (glycosylated G-CSF)-cells. The basal hyper-activation of RhoA could be responsible for the morphological and functional modifications of Filgrastim-mobilized cells. Moreover, Filgrastim-mobilized cells, but not Lenograstim-mobilized cells, are unable to correctly respond to LPS stimulation, as demonstrated by minor further RhoA activation and cell elongation.
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Authors
Letizia Mattii, Antonio Azzarà , Rita Fazzi, Giovanni Carulli, Massimo Chimenti, Nadia Cecconi, Sara Galimberti, Mario Petrini,