Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10909550 | Leukemia Research | 2005 | 5 Pages |
Abstract
Dimethylsulfoxide (DMSO) has been known to differentiate HL60 cells into neutrophil like cells. Here, we provide an evidence for the involvement of tumor suppressor PTEN, an antagonist of phosphatidylinositol 3-kinase (PI3K) in the DMSO-induced differentiation of HL60 cells. DMSO upregulated PTEN with unaffecting the expression of PI3K. The upregulation of PTEN by DMSO lead to the decrease of Akt phosphorylation, a downstream of PI3K. The DMSO-induced upregulation of PTEN might be mediated by NF-κB activation, which was evidenced by the blockage of DMSO-induced PTEN upregulation with an NF-κB inhibitor, pyrrolidine dithiocarbamate (PDTC).
Keywords
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Authors
Young-Rae Lee, Hyun-Jaung Shim, Hong-Nu Yu, Eun-Kyung Song, Jinny Park, Kang-Beom Kwon, Jin-Woo Park, Hye-Won Rho, Byung-Hyun Park, Myung-Kwan Han, Jong-Suk Kim,