| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10909566 | Leukemia Research | 2005 | 9 Pages |
Abstract
In this study, 107 children with acute lymphoblastic leukemia (ALL) were analysed for the presence of hyperdiploidy by cytogenetics and interphase fluorescence in situ hybridisation (I-FISH). Structural aberrations in hyperdiploid cells were investigated by multiple colour FISH (mFISH). Clones with high hyperdiploidy (>50 chromosomes) (HeH) were found in 46 patients (43%). In nine of these (20%), the abnormal clone was present in <20% of the total cell population. There was no significant difference in EFS between those patients with HeH in 2.5-20% or >20% of cells. Structural rearrangements in the HeH clone were found in 10 patients (22%). In this study, HeH karyotypes containing structural aberrations were an indication of a poor prognosis in childhood ALL.
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Authors
Zuzana Zemanova, Kyra Michalova, Lenka Sindelarova, Petr Smisek, Jana Brezinova, Sarka Ransdorfova, Vladimir Vavra, Alena Dohnalova, Jan Stary,