| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10909588 | Leukemia Research | 2005 | 6 Pages |
Abstract
To determine the clinical significance of the T helper 1(Th1)/T helper 2 (Th2) ratio in multiple myeloma, the intracellular IFN-γ and IL-4 were analyzed by flow cytometry in 56 patients with multiple myeloma. The mean Th1/Th2 ratio of cases in the initial diagnosis phase and the refractory phase were higher than that of the control group. The mean serum beta-2-microglobulin in the high Th1/Th2 subgroup was significantly higher than that in the normal Th1/Th2 subgroup (P < 0.05). In conclusion, the Th1/Th2 ratio was closely related to the disease status of multiple myeloma.
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Authors
Hatsue Ogawara, Hiroshi Handa, Tohru Yamazaki, Takuma Toda, Kensuke Yoshida, Natsumi Nishimoto, Wedad Hamdi Saleh Al-ma'Quol, Yoriaki Kaneko, Takafumi Matsushima, Norifumi Tsukamoto, Yoshihisa Nojima, Morio Matsumoto, Morio Sawamura, Hirokazu Murakami,