Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10909705 | Leukemia Research | 2005 | 11 Pages |
Abstract
Viscum album agglutinin-I (VAA-I) is a potent inducer of cell apoptosis and possesses anti-tumoral activity. Using PLB-985 and chronic granulomatous disease (X-CGD) cells, which lack expression of gp91phox, VAA-I was found to induce apoptosis in both cell lines as assessed by cytology, DNA laddering and degradation of the cytoskeletal protein gelsolin. Both cell lines expressed caspase-3 and -8 and VAA-I activated these caspases. We demonstrated that lamin B1 is a novel target to VAA-I and its degradation was reversed by a pan-caspase inhibitor and by a caspase-6, but not a caspase-8, inhibitor.
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Authors
Valérie Lavastre, Sonia Chiasson, Hélène Cavalli, Denis Girard,