| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10909711 | Leukemia Research | 2005 | 10 Pages |
Abstract
The T-cell population of a patient with persistent polyclonal B-cell lymphocytosis (PPBL) presenting with an intermittent Epstein-Barr virus (EBV)-associated disease was studied. Unstimulated T-cells did not express CD40 ligand (CD40L), whereas activation with IL-2 led to expression of this costimulatory molecule. CD40L expression was inhibited upon incubation with the supernatant of an EBV-positive B-cell line (SM) which had been grown spontaneously from the patient's peripheral blood cells. The supernatant of SM cells effectively inhibited cytotoxic T-cells. Elevated levels of IL-10, TNF-alpha and soluble CD40 were found in the supernatant of SM cells. Additionally, enhanced levels of LMP-1 protein were detected.
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Authors
Manfred Mitterer, Andrea J. Lanthaler, Eveline U. Irschick, Hartmut Engelmann, Clara Larcher, Hartwig P. Huemer,