Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10909730 | Leukemia Research | 2005 | 4 Pages |
Abstract
The t(8;21)(q22;q22) rearrangement is observed in about 15% of acute myelocitic leukemia (AML) cases, while variant t(8;21) translocations are detected in 6-10% of AML patients positive for the 5â²RUNX1/3â²CBFA2T1 fusion gene. We report a detailed molecular cytogenetic analysis of a four-way variant t(8;11;16;21)(q22;q14;q12;q22) performed by fluorescence in situ hybridization with specific BAC and PAC clones. The study demonstrated the loss of several megabases belonging to chromosomes 11 and 16 whereas no deletion was detected on der(21). These findings suggest that a precise breakpoint characterization could identify submicroscopic genomic deletions whose meaning remains to be defined.
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Authors
Francesco Albano, Giorgina Specchia, Luisa Anelli, Arcangelo Liso, Antonella Zagaria, Alessandra Santoro, Salvatore Mirto, Vincenzo Liso, Mariano Rocchi,