| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10909739 | Leukemia Research | 2005 | 7 Pages |
Abstract
TEL/AML1 fusion gene is present in 20-25% of childhood acute lymphoblastic leukaemias. In order to unravel at which stage of B-cell precursor development the fusion is originated, we analysed frequency and pattern of immunoreceptor (immunoglobulin and T-cell receptor) gene rearrangements in 47 TEL/AML1-positive and 43 TEL/AML1-negative cases of the same CD10+ immunophenotype. Moreover, we compared corresponding immunoreceptor gene rearrangements in 11 cases of TEL/AML1-positive leukaemia at diagnosis and relapse. More mature immunogenotype of TEL/AML1-positive cases and changes in 37% of rearrangements between diagnosis and relapse suggest that in most cases the TEL/AML1 fusion is formed during immunoreceptor gene rearrangement process.
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Authors
Jan Zuna, Ondrej Krejci, Jozef Madzo, Eva Fronkova, Lucie Sramkova, Ondrej Hrusak, Tomas Kalina, Martina Vaskova, Jan Stary, Jan Trka, The Czech Paediatric Haematology Working Group (CPH) The Czech Paediatric Haematology Working Group (CPH),