Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10910910 | Lung Cancer | 2014 | 21 Pages |
Abstract
In analysis for in vitro models, CRKL gene copy numbers were identical between EGFR-TKI-sensitive parental cells and their acquired resistant descendant cells. In addition, we found no clinical tumor specimens with acquired EGFR-TKI resistance to harbor amplified CRKL genes. These results indicate that CRKL gene amplification is rare in acquisition of resistance to EGFR-TKIs in lung cancer patients with EGFR mutations.
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Authors
Kenichi Suda, Hiroshi Mizuuchi, Isao Murakami, Hidetaka Uramoto, Fumihiro Tanaka, Katsuaki Sato, Toshiki Takemoto, Takuya Iwasaki, Yoshitaka Sekido, Yasushi Yatabe, Tetsuya Mitsudomi,