Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10911200 | Lung Cancer | 2014 | 7 Pages |
Abstract
We found that the expression levels of RASSF3 were frequently downregulated in NSCLCs. Downregulation of RASSF3 strongly correlated with the progressive phenotypes of NSCLCs and EGFR wild-type status. In vitro studies also suggested that RASSF3 downregulation increases migration ability of lung cancer cells. Together, our findings indicate RASSF3 is a candidate tumor suppressor gene of NSCLCs.
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Authors
Asuki Fukatsu, Futoshi Ishiguro, Ichidai Tanaka, Takumi Kudo, Kentaro Nakagawa, Keiko Shinjo, Yutaka Kondo, Makiko Fujii, Yoshinori Hasegawa, Kenji Tomizawa, Tetsuya Mitsudomi, Hirotaka Osada, Yutaka Hata, Yoshitaka Sekido,