Concurrent chemoradiotherapy for large-volume locally-advanced non-small cell lung cancer

Patients undergoing CRT for stage III NSCLC with a PTV > 700 cc, with or without N3 nodal disease, had a significantly shorter OS than patients with PTV ≤ 700 cc with N3. Patients with PTV > 700 cc and with CCI ≥ 1, had a significantly higher risk of early death but longer-term survivors with PTV > 700 cc are observed. The PTV and CCI should be considered in clinical decision making and used as stratification factors in future trials.