Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10911365 | Lung Cancer | 2012 | 5 Pages |
Abstract
Analysis of databases from transplant recipients revealed a 3-5 fold higher risk to develop de novo malignancies under continued immunosuppression. The underlying mechanisms are poorly understood. Here we describe a patient who received a bilateral lung transplantation for end-stage 'Usual Interstitial Pneumonia' (UIP) resulting in idiopathic lung fibrosis. The recipient presented with a non-small cell lung carcinoma (NSCLC) in the donor lung 7 months later. Molecular and immunological typing of the tumor revealed a cancer of donor origin with a prominent intratumoral immune cell infiltrate without detectable effector function. This is a unique case of de novo outgrowth of a NSCLC of donor origin under continued immunosuppression, supporting the concept of tumor immunosurveillance in vivo.
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Authors
Lotta von Boehmer, Alice Draenert, Wolfgang Jungraithmayr, Ilhan Inci, Schäfer Niklaus, Annette Boehler, Markus Hofer, Rolf Stahel, Alex Soltermann, Maries van den Broek, Walter Weder, Alexander Knuth,