Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10911508 | Lung Cancer | 2012 | 4 Pages |
Abstract
It was recently described that high FDG-uptake areas pre-radiotherapy largely correspond with residual metabolic-active areas post-radiotherapy. Here, an independent prospective validation of these results was performed using an overlap-fraction (OF) calculation of various FDG-uptake based thresholds. Data from twelve patients treated at Radboud University Nijmegen Medical Center with lung cancer were analyzed. All patients underwent two FDG-PET-CT scans, one pre-radiotherapy (pre-RT) and one approximately three months after treatment (post-RT). Of the twelve analyzed patients, eight patients showed residual FDG uptake on the post-RT scan and were included for analysis. One of these patients had a residue that was not clearly distinguishable from the surrounding tissue due to FDG avid inflammation. Therefore, seven patients remained for further analysis. The mean volume of the residual metabolic-active areas post-RT was 14.6 ± 10.0% (mean ± SD) of the mean volume of the gross tumour volume (GTV) pre-RT. The residual metabolic-active areas largely corresponded with the pre-RT GTV (OF = 93.7 ± 7.2%). The pre-RT-scan threshold delineations of 34%, 40% and 50% of the SUVmax had a large OF with the residual region, 86.9 ± 8.3%, 77.4 ± 8.1% and 67.9 ± 6.8%, respectively. In this independent dataset, we confirmed that the location of residual FDG-uptake areas after radiotherapy corresponds with the high FDG-uptake areas pre-radiotherapy. Therefore, a pre-radiotherapy FDG-PET-CT scan can potentially be used for radiotherapy dose redistribution.
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Authors
Hugo J.W.L. Aerts, Johan Bussink, Wim J.G. Oyen, Wouter van Elmpt, Annemieke M. Folgering, Daisy Emans, Marije Velders, Philippe Lambin, Dirk De Ruysscher,