An inhibitor of thrombin activated fibrinolysis inhibitor (TAFI) can reduce extracellular matrix accumulation in an in vitro model of glucose induced ECM expansion

► Blocking TAFI activity can lead to an increase in plasmin activity in kidney cells. ► Increased plasmin activity results in a decrease in ECM accumulation. ► First time that inhibition of TAFI has been shown to have a direct affect on ECM ► Could be quickly applied as treatment of chronic fibrosis due to clean toxicology