| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10913842 | Matrix Biology | 2012 | 7 Pages |
Abstract
⺠Neutrophil elastase (NE) is required for experimental bullous pemphigoid. ⺠NE directly cleaves BP180 in mouse and human skin. ⺠Recombinant murine BP180 is degraded into small peptides by NE. ⺠One small peptide is chemotactic for neutrophils in mice both in vitro and in vivo. ⺠Local injection of neutrophil elastase recruits neutrophils to the skin in mice.
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Authors
Lan Lin, Tomoko Betsuyaku, Lisa Heimbach, Ning Li, David Rubenstein, Steven D. Shapiro, Lijia An, George J. Giudice, Luis A. Diaz, Robert M. Senior, Zhi Liu,