| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10913845 | Matrix Biology | 2012 | 12 Pages |
Abstract
⺠A peptide (C-RLKEKH-C) mimicking the human CD11b-I-domain binding site was selected by phage display technology. ⺠It inhibits the binding of fibrinogen, complement protein iC3b, but not ICAM-1, to CD11b/CD18 integrin. ⺠The adhesion of PMNs to firbrinogen, and iC3b was blocked by the characterized peptide. ⺠The anti-inflammatory activity of the peptide was examined in a mouse model.
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Authors
Mehdi Houimel, Luca Mazzucchelli,