Article ID Journal Published Year Pages File Type
10913849 Matrix Biology 2012 7 Pages PDF
Abstract
► We examined the mineralization processes in Abcc6−/− mice, a model system for PXE, by energy dispersive X-ray, and Fourier transform infrared imaging spectroscopy (FT-IRIS). ► The principal components of the mineral deposits were calcium and phosphate. ► Determination of the mineral phases by FT-IRIS suggested progressive maturation of the mineral deposits from amorphous calcium phosphate to hydroxyapatite. ► These results provide critical information of the mechanisms of mineralization in PXE, with potential pharmacologic implications.
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