| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10913852 | Matrix Biology | 2012 | 10 Pages |
Abstract
⺠CyrA is a true matricellular protein that regulates cell motility. ⺠CyrA localizes to the ER and is secreted into the extracellular matrix. ⺠CyrA binds CaM and both proteins localize in the ECM deposited by migrating slugs. ⺠Capping of CyrA shows the presence of a surface receptor that mediates signaling. ⺠CyrA coimmunoprecipitates with vinculin B providing a cytoskeletal link.
Keywords
PLA2CaM-binding domainEGF-like repeatsmyosin II heavy chainCaMBPCaM-binding proteinCaMBOTCaMBDMatricellularDictyosteliumSPARCMMP2ECMImmunoprecipitatekiloDaltonGFPFITCTSPPI3KkDaEGFRphospholipase A2Cell motilityThrombospondinCAMWhole cellendoplasmic reticulumepidermal growth factor-likeCysteine-richPhosphatidylinositol 3-kinasefluorescein isothiocyanateExtracellular matrixmatrix metalloproteinase 2MHCsecreted protein, acidic and rich in cysteinegreen fluorescent proteinacyl-CoA binding proteinCalmodulin-binding proteinCalmodulinEGF receptor
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Authors
Robert J. Huber, Andres Suarez, Danton H. O'Day,