Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10913967 | Matrix Biology | 2005 | 14 Pages |
Abstract
Polypeptide sequences encoded by some exons of the human tropoelastin gene (EDP, elastin-derived peptide) have been analysed for their ability to coacervate and to self-assembly. The great majority of them were shown to form organized structures, but only a few were indeed able to coacervate. Negative staining and rotary shadowing transmission electron microscopy showed the polypeptides to adopt a variety of supramolecular organization, from filaments, as those typical of tropoelastin, to amyloid-like fibers. The results obtained gave significant insight to the possible roles played by specific polypeptide sequences of tropoelastin.
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Authors
Antonietta Pepe, Deanna Guerra, Brigida Bochicchio, Daniela Quaglino, Dealba Gheduzzi, Ivonne Pasquali Ronchetti, Antonio M. Tamburro,