Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs

Article ID	Journal	Published Year	Pages	File Type
10914518	Molecular Oncology	2016	46 Pages	PDF

Keywords

LKB1 PDAC Dorsomorphin AMPK activation CHK2 HSP27 2-Deoxyglucose CD133 PARP N-acetyl-l-cysteine ESA NAC AMPK ACC GSH 2-DG 5′ AMP-activated protein kinase MEI p38-MAPK ROS Pancreatic ductal adenocarcinoma acetyl-CoA carboxylase indirubin epithelial cell adhesion molecule p38 mitogen-activated protein kinase poly ADP ribose polymerase liver kinase B1 Glutathione Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research

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Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs

Authors

Xinlai Cheng, Jee Young Kim, Shahrouz Ghafoory, Tijen Duvaci, Roya Rafiee, Jannick Theobald, Hamed Alborzinia, Pavlo Holenya, Johannes Fredebohm, Karl-Heinz Merz, Arianeb Mehrabi, Mohammadreza Hafezi, Arash Saffari, Gerhard Eisenbrand,