| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10914535 | Molecular Oncology | 2016 | 12 Pages |
Abstract
Down regulation of proteins involved in HRR or ICLR by mTOR inhibitors is associated with increased sensitivity of human tumours to Chk1 inhibitors such as V158411. High levels of DNA-PKcs may be a potential biomarker to stratify patients to Chk1 inhibitor therapy alone or in combination with mTOR inhibitors.
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Authors
Andrew J. Massey, Peter Stephens, Rebecca Rawlinson, Lauren McGurk, Ruth Plummer, Nicola J. Curtin,