Targeted capture massively parallel sequencing analysis of LCIS and invasive lobular cancer: Repertoire of somatic genetic alterations and clonal relationships

Article ID	Journal	Published Year	Pages	File Type
10914556	Molecular Oncology	2016	11 Pages	PDF

Abstract

LCIS and ILC have a similar repertoire of somatic mutations, with PIK3CA and CDH1 being the most frequently mutated genes. The presence of identical mutations between LCIS-LCIS and LCIS-ILC pairs demonstrates that LCIS is a clonal neoplastic lesion, and provides additional evidence that at least some LCIS are non-obligate precursors of ILC.

Keywords

Burrows-Wheeler aligner BWA GATK SNV TCGA MAF LCIS ILC MSKCC H&E Genome Analysis Toolkit loss of heterozygosity The cancer genome atlas Massively parallel sequencing insertions and deletions LOH Memorial Sloan Kettering Cancer Center Hematoxylin and Eosin Indels Lobular carcinoma in situ Invasive lobular carcinoma Clonality Estrogen receptor single nucleotide variant

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Targeted capture massively parallel sequencing analysis of LCIS and invasive lobular cancer: Repertoire of somatic genetic alterations and clonal relationships

Authors

Rita A. Sakr, Michail Schizas, Jose V. Scarpa Carniello, Charlotte K.Y. Ng, Salvatore Piscuoglio, Dilip Giri, Victor P. Andrade, Marina De Brot, Raymond S. Lim, Russell Towers, Britta Weigelt, Jorge S. Reis-Filho, Tari A. King,