| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10914576 | Molecular Oncology | 2016 | 12 Pages |
Abstract
A variety of molecular assays have been developed for CTCs detection and molecular characterization. Molecular assays are based on the nucleic acid analysis in CTCs and are based on total RNA isolation and subsequent mRNA quantification of specific genes, or isolation of genomic DNA that can be for DNA methylation studies and mutation analysis. This review is mainly focused on gene expression and methylation studies in CTCs in various types of cancer.
Keywords
aCGHMultiplex RT-PCRMUC-1CK-19Brms1SOX17Cystatin MPBGDHER-2EpCAMMSPMBCRT-qPCRRNA-seqCTCsRT-PCRCTCCtDNAqPCRCeAmethylation specific PCRQuantitative PCRQuantitative PCR (qPCR)array-Comparative Genomic Hybridizationcarcinoembryonic antigenGene expressionMolecular assaysRNA-sequencingCirculating tumor cellsMolecular characterizationreverse transcription PCRreverse transcription quantitative polymerase chain reactionMetastatic breast cancercytokeratin 19epithelial cell adhesion moleculeporphobilinogen deaminasecirculating tumor DNAHuman epidermal growth factor receptor 2
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Authors
Evi S. Lianidou,