Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10914609 | Molecular Oncology | 2015 | 11 Pages |
Abstract
Our results show that TOP1 and TOP2A gene copy numbers are increased in the pMMR subgroup. We propose that this preference may reflect a selective pressure to gain and/or maintain the gained extra copies of topoisomerase genes whose products are required to cope with high replication stress present in the pMMR tumors, thereby providing a survival advantage selectively in pMMR tumors. Future studies should test this concept and explore potential differences between pMMR and dMMR tumors in response to Top1 and Top2 inhibitors.
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Authors
Ida Marie Heeholm Sønderstrup, Sune Boris NygÃ¥rd, Tim Svenstrup Poulsen, Dorte Linnemann, Jan Stenvang, Hans Jørgen Nielsen, Jiri Bartek, Nils Brünner, Peter Nørgaard, Lene Riis,