| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10914641 | Molecular Oncology | 2014 | 12 Pages |
Abstract
We have shown that molecular subtypes have a different distribution and prognostic effect in elderly compared to young breast cancer patients, emphasizing the fact that biomarkers may have different distributions and prognostic effects and therefore different implications in elderly compared to their younger counterparts. Our results support the premise that breast cancer clinical behavior is significantly affected by patient age. We suggest that competing risks of death in elderly patients, ER-driven differences and micro-environmental changes in biology are underlying these age-dependent variations in patient prognosis.
Keywords
number of patientsEGFRRFPVSTRERHER2RSN95 percent confidence interval95%CIImmunohistochemistryIHCRelative survivalBreast conservative surgeryEndocrine therapyRadiotherapyBCsMolecular subtypesElderlyBreast cancerChemotherapyMastectomymasthazard ratioPrognosticationEstrogen receptorHuman epidermal growth factor receptor 2Epidermal growth factor receptorProgesterone receptor
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Authors
Esther M. de Kruijf, Esther Bastiaannet, Francesca Rubertá, Anton J.M. de Craen, Peter J.K. Kuppen, Vincent T.H.B.M. Smit, Cornelis J.H. van de Velde, Gerrit Jan Liefers,