| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10914699 | Molecular Oncology | 2015 | 14 Pages |
Abstract
SN-38 cytotoxicity is S-phase dependent. Vaccinia virus results in an accumulation of both infected and uninfected cells in S-phase phase. The virus-mediated increase in S-phase among cells that are either uninfected or in the early stages of viral infection, leads to increased SN-38-induced apoptosis and synergistic tumour killing.219
Keywords
DPIPFAHBSSMOA7-AAD7-aminoactinomycin DCPT-11RFP5-FUTNFMOIstandard deviationOxaliplatinIrinotecanIHCImmunohistochemistrystandard error of the meanintraperitonealCombination therapydays post-infectionColorectal cancerMetastatic colorectal cancercombination indexChemotherapytumour necrosis factor5-fluorouracilTRAILLeucovorinHank's balanced salt solutionSEMMechanism of actionplaque forming unitOncolytic virusvaccinia virusOncolytic virotherapyparaformaldehydered fluorescent proteinpfumultiplicity of infectionCRCfraction affected
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Authors
Kathryn Ottolino-Perry, Sergio A. Acuna, Fernando A. Angarita, Clara Sellers, Siham Zerhouni, Nan Tang, J. Andrea McCart,