Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10914704 | Molecular Oncology | 2015 | 14 Pages |
Abstract
Overall, our results indicate that autophagy modulation triggers a molecular switch from a mesenchymal phenotype to an epithelial-like one in GBM cellular models. Since the aggressiveness and lethality of GBM is defined by local invasion and resistance to chemotherapy, we believe that our evidence provides a further rationale for including autophagy/mTOR-based targets in the current therapeutical regimen of GBM patients.
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Authors
Myriam Catalano, Giuseppina D'Alessandro, Francesca Lepore, Marco Corazzari, Sara Caldarola, Cristina Valacca, Fiorella Faienza, Vincenzo Esposito, Cristina Limatola, Francesco Cecconi, Sabrina Di Bartolomeo,