Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10914741 | Molecular Oncology | 2014 | 11 Pages |
Abstract
We identified the small GTPase RHOB as a gene that promotes early and late stages of metastasis in ADC. Gene silencing of RHOB prevented metastatic activity in a systemic murine model of bone metastasis. These effects were highly dependent on tumor-host interactions. Clinical analysis revealed a marked association between high RHOB levels and poor survival. Consistently, high RHOB levels promote metastasis progression, taxane-chemoresistance, and contribute to the survival advantage to γ-irradiation. We postulate that RHOB belongs to a novel class of “genes of recurrence” that have a dual role in metastasis and treatment resistance.
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Authors
Diego Luis-Ravelo, Iker Antón, Carolina Zandueta, Karmele Valencia, MarÃa-José Pajares, Jackeline Agorreta, Luis Montuenga, Silvestre Vicent, Ignacio I. Wistuba, Javier De Las Rivas, Fernando Lecanda,