| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10914890 | Molecular Oncology | 2013 | 12 Pages |
Abstract
⺠Asbestos-exposure related genomic markers are proposed in lung cancer (LC) patients. ⺠Allelic imbalances in 2p16, 9q33.1 and 19p13 occur in LC normal pulmonary epithelium. ⺠Changes in 2p16, 9q33.1 and 19p13 in combination associate with asbestos in LC. ⺠The association of these genetic changes to asbestos exposure is dose-dependent. ⺠The alterations form the basis for the development of a combinatorial molecular assay.
Keywords
DBC1TSGSCCCNATMABACFFPEAdenocarcinoma of the lungloss of heterozygosityPulmonary epitheliumSCLCMicrosatelliteLung cancerSquamous cell lung cancerSmall-cell lung cancerNSCLCNon-small cell lung cancerAllelic imbalanceformalin-fixed paraffin-embeddedfluorescence in situ hybridizationAsbestos exposureLOHFishTissue microarrayTumour suppressor genebacterial artificial chromosomeCopy number alteration
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Authors
Penny Nymark, Mervi Aavikko, Jussi Mäkilä, Salla Ruosaari, Tuija Hienonen-Kempas, Harriet Wikman, Kaisa Salmenkivi, Risto Pirinen, Antti Karjalainen, Esa Vanhala, Eeva Kuosma, Sisko Anttila, Eeva Kettunen,