| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10914896 | Molecular Oncology | 2013 | 9 Pages |
Abstract
⺠PC9/gef cells are 270-fold resistant than PC9 cells to gefitinib. ⺠PC9/gef cells contain EGFR del 19 mutation but not EGFR T790M or MET amplification. ⺠NRAS Q61K mutation is found in all PC9/gef cells. ⺠ERK phosphorylation can not be suppressed by gefitinib in PC9/gef cells. ⺠MEK inhibitors plus gefitinib inhibit growth of PC9/gef cells in vitro and in vivo.
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Authors
Ming-Hung Huang, Jih-Hsiang Lee, Ya-Ju Chang, Hsin-Hui Tsai, Yu-Lin Lin, Anya Maan-Yuh Lin, James Chih-Hsin Yang,