Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10914941 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2013 | 5 Pages |
Abstract
Bisphenol A (BPA), a monomer used in the manufacture of epoxy, polycarbonate, and polystyrene resins, is a xenoestrogen present in many consumer products. We investigated the effects of 2-week exposure to BPA, either alone or in combination with X-rays, on the induction of DNA damage in somatic cells of female mice in vivo. The micronucleus and alkaline comet assays were used to evaluate genotoxicity. BPA induced DNA strand breaks in lung cells but not in bone marrow lymphocytes, liver, kidney, or spleen cells. Induction of micronuclei was observed only in polychromatic reticulocytes of peripheral blood. Levels of damage following combination exposure to ionizing radiation plus BPA depended on tissue, assay, and time.
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Authors
Aneta Gajowik, Joanna Radzikowska, MaÅgorzata M. DobrzyÅska,