| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10914946 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2013 | 9 Pages |
Abstract
The results obtained during this preliminary assessment indicate that the in vitro γH2AX assay has a high accuracy (86%) as a result of high sensitivity and specificity (86-92% and 80-88% respectively). Our data highlight the potential for γH2AX detection in HCS as a complement to the current regulatory genotoxicity battery of in vitro assays. We therefore recommend more comprehensive assessments to confirm the performance of the in vitro γH2AX assay by HCS with a more extensive set of compounds.
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Authors
Carolina Garcia-Canton, Arturo Anadon, Clive Meredith,