Article ID Journal Published Year Pages File Type
10914976 Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2013 6 Pages PDF
Abstract

- The effects of furazolidone on S phase cell cycle arrest of HepG2 were studied.
- Furazolidone can suppress the cell proliferation of HepG2 in vitro.
- Activated p-p38 can inhibit p-JNK activity in HepG2 induced by furazolidone.
- FZD induces cell cycle arrest via activating p38 MAPK and inhibiting JNK.
- P38 and JNK have opposing effects on FZD-induced S phase cell cycle arrest.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
Preview
Opposite effects of JNK and p38 MAPK signaling pathways on furazolidone-stimulated S phase cell cycle arrest of human hepatoblastoma cell line
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