| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10914989 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2012 | 6 Pages |
Abstract
⺠TK6 cells are suitable for the MNvit assay in accordance with OECD guideline TG487. ⺠Extended recovery period after treatment improves sensitivity of TK6 cells. ⺠Negative controls showed reproducibly low and consistent micronucleus frequencies. ⺠MNvit assay in TK6 cells clearly differentiates negative and positive compounds. ⺠MNvit assay in TK6 cells detects clastogens and aneugens with varying mechanisms.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Zhanna Sobol, Michael L. Homiski, Donna A. Dickinson, Richard A. Spellman, Dingzhou Li, Andrew Scott, Jennifer R. Cheung, Stephanie L. Coffing, Jennifer B. Munzner, Kelley E. Sanok, William C. Gunther, Krista L. Dobo, Maik Schuler,