| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10914996 | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2012 | 11 Pages |
Abstract
⺠CP31398, SHetA2 and PI were negative in the Ames test and in the mouse bone marrow micronucleus test. ⺠CP31398 and SHetA2 were negative for chromosomal aberrations (CA) in CHO cells. ⺠PI was negative in the absence of S9 and positive in the presence of S9 for CA in CHO cells. ⺠Induction of CA with PI in the presence of S9 may be due to the metabolites generated in cultures. ⺠All 3 compounds may be potential chemopreventive agents for further development.
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Authors
Rupa S. Doppalapudi, Edward S. Riccio, Zoe Davis, Sean Menda, Abraham Wang, Nicholas Du, Carol Green, Levy Kopelovich, Chinthalapally V. Rao, Doris M. Benbrook, Izet M. Kapetanovic,