Article ID Journal Published Year Pages File Type
10915051 Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2005 6 Pages PDF
Abstract
We observed an inverse correlation between the plasma TAR and the levels of endogenous DNA damage (r = −0.64, p < 0.01), in that the levels of oxidative damage to the DNA were found to parallel the decrease in the plasma TAR in the CHM group. These results reveal a relationship between the extracellular and intracellular (as reflected by damage to the DNA) levels of oxidation. Our observations suggest that there is a link between the increased levels of oxidative stress and the increase in endogenous DNA damage seen in patients with CHM, as compared with those seen in normal pregnancy. However, the nature of this link, and whether it is direct or indirect, remains to be explored.
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