Trithiols and their arsenic compounds for potential use in diagnostic and therapeutic radiopharmaceuticals

The high yield and stability of a single NCA 77As trithiol complex indicates that this framework is suitable for developing matched pair agents for non-invasive in vivo PET imaging and radiotherapy of tumors with 72,77As. This is the first reported chelate developed for NCA radioarsenic and studies are underway for developing a trithiol bifunctional chelate conjugated to a targeting vector, such as a peptide or monoclonal antibody.