Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10915907 | Nuclear Medicine and Biology | 2015 | 13 Pages |
Abstract
Two novel diabodies with excellent binding affinity and specificity for the αvβ6 integrin in vitro were developed. Radiolabeling of the diabodies with fluorine-18 ([18F]) and [64Cu] revealed advantages and disadvantages with regards to methodologies and RCYs, however immunoreactivities were well preserved regardless of radiolabeling approach.
Keywords
ECMImmuno-PETSFBNi-NTAPSCAkDamAbsscFvOSCCCDRSECRCYRCPHER2ITLCαvβ6 integrinMMPCeASingle chain Fvcarcinoembryonic antigenProstate stem cell antigenenzyme-linked immunosorbant assaySDS-PAGESodium dodecyl sulfate polyacrylamide gel electrophoresisSize-exclusion chromatographyELISAradiochemical purityDiabodyRadiolabelingRadiochemical yieldFluorine-18Extracellular matrixmatrix-metalloproteinaseCopper-64ALCAMcomplementary determining regionactivated leukocyte cell adhesion moleculeNickel Nitrilotriacetic acidsite-specific conjugationMonoclonal antibodiesoral squamous cell carcinomahigh performance liquid chromatographyHPLCkilodaltonsHuman epidermal growth factor receptor 2
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Authors
Jason B. White, David L. Boucher, Kirstin A. Zettlitz, Anna M. Wu, Julie L. Sutcliffe,