| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10915913 | Nuclear Medicine and Biology | 2015 | 7 Pages |
Abstract
We have described the synthesis and in vivo evaluation of a novel radioligand for PDE7 imaging. Despite high uptake in the brain and favorable kinetics in vivo, the presence of a brain penetrant radiometabolite makes [18F]MICA-003 unfavorable for the accurate quantification of PDE7 and more stable spiroquinazolinones analogs are in development.
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Authors
David Thomae, Stijn Servaes, Naiara Vazquez, Leonie wyffels, Stefanie Dedeurwaerdere, Pieter Van der Veken, Jurgen Joossens, Koen Augustyns, Sigrid Stroobants, Steven Staelens,