| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10915923 | Nuclear Medicine and Biology | 2015 | 8 Pages |
Abstract
Using VHH-Fc conjugates increases the blood half-life of the protein. However, purely extending the time window for brain uptake does not increase BBB passage. Nevertheless, VHH-Fc holds promise for therapeutic applications where a sustained systemic circulation of VHH is advantageous.
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Authors
Maarten Rotman, Mick M. Welling, Marlinde L. van den Boogaard, Laure Grand Moursel, Linda M. van der Graaf, Mark A. van Buchem, Silvère M. van der Maarel, Louise van der Weerd,