Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10915948 | Nuclear Medicine and Biology | 2015 | 8 Pages |
Abstract
An efficient microfluidic synthetic method was developed for preparation of [18F]-(-)-NCFHEB. PET examination in rhesus monkeys showed that [18F]-(-)-NCFHEB entered the brain readily and its regional radioactivity uptake pattern was in accordance with the known distribution of α4β2 receptors. Estimated non-displaceable binding potential (BPND) values in brain regions were better than those of [18F]2-FA and comparable to [18F]AZAN. These results confirm previous findings and support further examination of [18F]-(-)-NCFHEB in humans.
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Authors
Frederic Bois, Jean-Dominique Gallezot, Ming-Qiang Zheng, Shu-Fei Lin, Irina Esterlis, Kelly P. Cosgrove, Richard E. Carson, Yiyun Huang,