| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10916004 | Nuclear Medicine and Biology | 2014 | 9 Pages |
Abstract
68Ga-NODAGA-E[c(RGDyK)]2 and 64Cu-NODAGA-E[c(RGDyK)]2 can be easily synthesized and are both promising candidates for PET imaging of integrin αVβ3 positive tumor cells. 68Ga-NODAGA-E[c(RGDyK)]2 showed slightly more stable tumor retention. With the advantage of in-house commercially 68Ge/68Ga generators, 68Ga-NODAGA-E[c(RGDyK)]2 may be the best choice for future clinical PET imaging in humans.
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![Comparison of two new angiogenesis PET tracers 68Ga-NODAGA-E[c(RGDyK)]2 and 64Cu-NODAGA-E[c(RGDyK)]2; in vivo imaging studies in human xenograft tumors](/preview/png/10916004.png "First Page Preview: Comparison of two new angiogenesis PET tracers 68Ga-NODAGA-E[c(RGDyK)]2 and 64Cu-NODAGA-E[c(RGDyK)]2; in vivo imaging studies in human xenograft tumors")
Authors
Jytte Oxboel, Malene Brandt-Larsen, Christina Schjoeth-Eskesen, Rebecca Myschetzky, Henrik H. El-Ali, Jacob Madsen, Andreas Kjaer,