[18Â F]-(fluoromethoxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)propan-2-ol ([18Â F FPTC) a novel PET-ligand for cerebral beta-adrenoceptors

'Click chemistry' was successfully applied to the synthesis of [18 F]FPTC resulting in high radiochemical yields. [18 F]FPTC showed specific binding in vitro, but not in vivo. Based on the logP value and its ability to block [125I]ICYP binding to C6 cells, FPTC may be a lead to suitable cerebral β-AR ligands.