| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10916039 | Nuclear Medicine and Biology | 2014 | 9 Pages |
Abstract
Hypersensitivity to non-internalizing 125I-mAbs is not due to lack of detection of DNA damage after low absorbed dose-rates. However, DNA double strand breaks accumulate in cells exposed both to internalizing and non-internalizing 125I-mAbs and lead to micronuclei formation. These results suggest impairment in DNA double strand breaks repair after low absorbed doses of 125I-mAbs.
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Authors
Bérengère Piron, Salomé Paillas, Vincent Boudousq, André Pèlegrin, Caroline Bascoul-Mollevi, Nicolas Chouin, Isabelle Navarro-Teulon, Jean-Pierre Pouget,