Article ID Journal Published Year Pages File Type
10916073 Nuclear Medicine and Biology 2013 8 Pages PDF
Abstract
Radioconjugate of IGF-1R siRNA, p-SCN-Bn-DTPA and 177Lu was successfully produced and characterized as radiopharmaceutical. The present study demonstrates the involvement of 177Lu-labeled IGF-1R siRNA in the inhibition of cell growth and induction of apoptosis in colon cancer cells.
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Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
Preview
Demonstration of dose dependent cytotoxic activity in SW480 colon cancer cells by 177Lu-labeled siRNA targeting IGF-1R
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