Palladium mediated 11C-cyanation and characterization in the non-human primate brain of the novel mGluR5 radioligand [11C]AZD9272

A fast and efficient method was developed to label AZD9272 with 11C. PET-examination in Cynomolgus monkeys showed that [11C]AZD9272 entered the brain to a high extent, that binding was saturable and that the regional radioactivity pattern was in accordance with the known distribution of mGluR5. The results support further examination of [11C]AZD9272 binding in human subjects.