Article ID Journal Published Year Pages File Type
10916085 Nuclear Medicine and Biology 2012 13 Pages PDF
Abstract
P450s catalyzed the formation of dealkylated and hydroxylated metabolites of LBT-999. In baboons, an extensive metabolism of [18F]LBT-999, with formation of unlabeled N-dealkyl-LBT-999, [18F]fluorobutenaldehyde (or its oxidation product) and [18F]hydroxy-LBT-999 able to penetrate the brain, prevented an easy and accurate estimation of the input function of the radiotracer. CYP3A4 being the main P450 involved in the metabolism of LBT-999, a similar pathway may occur in humans and confound PET quantification.
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